Evaluation of Angiogenesis in Multiple Myeloma by VEGF Immunoexpression and Microvessel Density
نویسندگان
چکیده
منابع مشابه
Clinical significance of microvessel density in multiple myeloma patients.
To investigate the role of angiogenesis in multiple myeloma (MM), bone marrow biopsy from 75 adults with newly diagnosed, untreated MM were evaluated. Microvessels were scored in at least 3 areas ( x 200 fields) of the highest microvessel density in representative sections of each bone marrow specimen using immunohistochemistry for CD34. Prognostic variables were also evaluated for the overall ...
متن کاملMicrovessel density and VEGF expression in pituitaries of pregnant women.
OBJECTIVE In pregnant women, the pituitary is enlarged and the prolactin (PRL) secreting cells increase in size and number. This PRL cell hyperplasia is associated with hyperprolactinemia. The aim of the present work was to investigate adenohypophysial vascularization and immunoexpression of vascular endothelial growth factor (VEGF) in pituitaries of pregnant and post-partum women and compare t...
متن کاملmiR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF.
Deregulated microRNAs (miRNAs) and their roles in cancer development have attracted much attention. Two miRNAs, miR-15a and miR-16, which act as putative tumor suppressor by targeting the oncogene BCL2, have been implicated in cell cycle, apoptosis and proliferation. In this study, we investigated the possible role of miR-15a/16 in the angiogenesis of multiple myeloma (MM). Using a stem-loop ...
متن کاملAnatomic Pathology / MICROVESSEL DENSITY AND VEGF IN LIVER CANCER
Assessment of angiogenesis may yield important information for an effective antiangiogenic treatment for hepatocellular carcinoma (HCC) because HCC is characteristically hypervascular. We examined the relationship of microvessel density (MVD), vascular endothelial growth factor (VEGF), and VEGF receptors Flt-1 and Flk-1/KDR in 50 patients with HCC and in 3 hepatoma cell lines. VEGF messenger RN...
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ژورنال
عنوان ژورنال: Journal of Laboratory Physicians
سال: 2020
ISSN: 0974-2727,0974-7826
DOI: 10.1055/s-0040-1714933